Meanwhile, exhibited low biological toxicity and intracellular free radical scavenging ability. Moreover, the photothermal property of CuS improved the broad-spectrum free radical scavenging efficiency of and its H 2O 2 clearance rate increased by 47.3% under NIR-II irradiation. Compared with the TA-free CuS nanoparticles, exhibited excellent photothermal property in the NIR-II region, which is ascribed to the TA-induced Cu defects and doped CuO. Systematic characterization demonstrated that the introduction of polyphenol (tannic acid (TA)) induced the formation of a CuO-doped heterogeneous structure and CuS nanoparticles.

Herein, we report a method inspired by the albumin-triggered biomineralization process with polyphenol-assisted strategy to prepare nanoparticles with NIR-II-targeted photo-enhanced antioxidant capacity. Several studies have focused on the direct scavenging of free radicals, however, the strategy of precisely controlling antioxidant activities remotely and spatiotemporally has rarely been reported.

The oxidative stress is a state of imbalance in the body's oxidative balance, which can cause or worsen many diseases.

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